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METHOTREXATE SHOULD BE USED ONLY IN LIFE THREATENING NEOPLASTIC DISEASES.OR IN PATIENTS WITH PSORIASIS OR RHEUMATOID ARTHRITIS WITH SEVERE.RECALCITRANT.DISABLING DISEASE WHICH IS NOT ADEQUATELY RESPONSIVE TO OTHER FORMS OF THERAPY.
After absorption.methotrexate undergoes hepatic and intracellular metabolism to polyglutamated forms which can be converted back to methotrexate by hydrolase purchase methotrexate sodium. These polyglutamates act as inhibitors of dihydrofolate reductase and thymidylate synthetase. Small amounts of methotrexate polyglutamates may remain in tissues for extended periods. The retention and prolonged drug action of these active metabolites vary among different cells.tissues and tumors. A small amount of metabolism to 7-hydroxymethotrexate may occur at doses commonly prescribed. Accumulation of this metabolite may become significant at the high doses used in osteogenic sarcoma. The aqueous solubility of 7- hydroxymethotrexate is 3 to 5 fold lower than the parent compound. Methotrexate is partially metabolized by intestinal flora after oral administration.
Tell your doctor if you or your partner is pregnant or plan to become pregnant. If you are purchase methotrexate sodium.you will need to take a pregnancy test before you begin taking methotrexate. Use a reliable method of birth control so that you or your partner will not become pregnant during or shortly after your treatment. If you are male.you and your female partner should continue to use birth control for 3 months after you stop taking methotrexate. If you are female.you should continue to use birth control until you have had one menstrual period that began after you stopped taking methotrexate. If you or your partner become pregnant.call your doctor immediately. Methotrexate may cause harm or death to the fetus.
Methotrexate is also sometimes used to treat Crohn’s disease (condition in which the immune system attacks the lining of the digestive tract.causing pain.diarrhea.weight loss and fever).multiple sclerosis (MS. condition in which the immune system attacks the nerves.causing weakness.numbness.loss of muscle coordination.and problems with vision.speech.and bladder control).and other autoimmune diseases (conditions that develop when the immune system attacks healthy cells in the body by mistake). Ask your doctor about the risks of using this medication for your condition.
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