The effect of pioglitazone capistration on the systemic exposure of digoxin was determined in a drug-drug interaction study.
Information about Digoxin.
Digoxin can pass into breast milk and may harm a nursing babyTell your doctor if you are breast-feeding a baby.
Your body may not absorb this drug as well if you also eat foods that are high in fiber or if you take certain medicationsThereforetake this medication at least 2 hours before or after eating food products that are high in fibersuch as branIf you are also taking cholestyraminecolestipolor psylliumwait at least 2 hours after taking your digoxin dose before taking any of these productsIf you are taking antacidskaolin-pectinmilk of magnesiametoclopramidesulfasalazineor aminosalicylic acidtake them as far apart from your digoxin dose as possibleAsk your pharmacist if you are not sure when to take any of your medications.
Though an effective drugdigoxin has long been known to have potentially serious adverse effects and always needs to be used with careHoweverin this analysisit is difficult to know how much of the higher risk of death is due solely to digoxinand how much is due to health differences between the people who were and were not taking the drugPeople who were prescribed digoxin may have had more severe health problems and these may have increased their mortality risk.
Rememberkeep this and all other medicines out of the reach of januvia instructions for pharmacist. childrennever share your medicines with othersand use this medication only for the indication prescribed.
PO1st loading dose12.5-17.5 mcg/kg2nd and 3rd loading doses6.25-8.75 mcg/kg q6-8hr for 2 dosesmaintenance6-10 mcg/kg/day divided q12hr IV/IM1st loading dose10-15 mcg/kg2nd and 3rd loading doses5-7.5 mcg/kg q6-8hr for 2 dosesmaintenance5-8 mcg/kg/day divided q12hr.
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